Abstract
Induction of gene conversion in diploid yeast strains BZ34 and D7 was investigated following exposure to cigarette smoke condensate (CSC) and gamma radiation. Cells treated with CSC for 1 h showed 5–10-fold increase in gene conversion over the background frequency. Log-phase cells were 2–3 times more sensitive compared to stationary-phase cells. Cells exposed to a combination of CSC and radiation suggested an additive response of the 2 agents, irrespective of the order of the 2 treatments.
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