Abstract
BackgroundThe prognostic role of BDNF val66met polymorphism on long-term cardiac outcomes in acute coronary syndrome (ACS) has been unclear. Environmental factors may modify the association, but these have not been investigated to date. This study aimed to investigate the potential interactive effects of BDNF val66met polymorphism and personality traits, one of the main environmental prognostic factors of ACS, on major adverse cardiac events (MACEs) in patients with ACS.MethodsA total of 611 patients with recent ACS were recruited at a university hospital in Korea. Baseline evaluations from 2007 to 2012 assessed BDNF val66met polymorphism and personality using the Big Five Inventory, which yielded two personality clusters (resilient and vulnerable) and five dimensions (extraversion, agreeableness, conscientiousness, neuroticism, and openness). Over a 5~12 year follow-up after the index ACS, times to MACE were investigated using Cox regression models after adjustment for a range of covariates.ResultsThe BDNF val66met polymorphism modified the associations between vulnerable personality type and worse long-term cardiac outcomes in ACS patients with significant interaction terms, in that the associations were statistically significant in the presence met allele. Similar findings were observed for the individual personality dimensions of agreeableness and neuroticism.ConclusionsGene (BDNF val66met polymorphism) x environment (personality traits) interactions on long-term cardiac outcomes were found in ACS.
Highlights
Acute coronary syndrome (ACS), including myocardial infarction (MI) and unstable angina (UA), is a global leading cause of disease burden associated with increased morbidity and mortality [1]
The brain derived neurotrophic factor (BDNF) val66met polymorphism modified the associations between vulnerable personality type and worse long-term cardiac outcomes in acute coronary syndrome (ACS) patients with significant interaction terms, in that the associations were statistically significant in the presence met allele
The funders had no role in study design and conduct of the study; in the collection, management, analysis, and interpretation of data; in the preparation, review, or approval of the manuscript; and in the decision to submit the manuscript for publication
Summary
Acute coronary syndrome (ACS), including myocardial infarction (MI) and unstable angina (UA), is a global leading cause of disease burden associated with increased morbidity and mortality [1]. Gene-environment interactions (GEI) in human diseases have been received increasing research attention [4]. We recently published the interactive effect of anxiety and serotonin transporter gene on long-term cardiac outcomes in ACS [8]. The prognostic role of BDNF val66met polymorphism on long-term cardiac outcomes in acute coronary syndrome (ACS) has been unclear. This study aimed to investigate the potential interactive effects of BDNF val66met polymorphism and personality traits, one of the main environmental prognostic factors of ACS, on major adverse cardiac events (MACEs) in patients with ACS
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