Interaction between a variant of chromosome 9p21.3 locus and diet antioxidant capacity on metabolic syndrome in Tehrani adults

Atieh Mirzababaei,Mir Saeed Yekaninejad,Reza Sobhani,Khadijeh Mirzaei,Mohammad Hossein Rahimi,Mehdi Mollahosseini,Zhila Maghbooli

doi:10.1186/s13098-018-0372-z

Abstract

BackgroundGenome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have potential favorable effects on MetS prevention. This study examined the interactions between rs1333048 genotypes on 9p21 genetic region and Total antioxidant capacity (TAC) on odds of MetS.Methods263 Tehrani adults were enrolled in this cross-sectional study. The MetS was defined according to the ATPIII. Dietary intake was assessed daily using a FFQ with 147 items. Dietary TAC was assessed according to United States Department of Agriculture database for oxygen radical absorbance capacity (ORAC). Bioelectrical impedance analysis method was used for body analysis and rs1333048 were genotyped by restriction fragment length polymorphism method. Participants were categorized into three groups based on rs1333048 genotypes.ResultsThe results demonstrate that, prevalence of C allele was 52.85% and A allele was 47.15%. After adjustment for confunder variable, this study demonstrated an interaction between AA genotype and high Lyophilic oxygen radical absorbance capacity (L-ORAC) and high Hydrophilic oxygen radical absorbance capacity (H-ORAC) intake on low odds of MetS (OR = 0.24, 95% CI = 0.06–0.94, P for interaction = 0.04, OR = 0.26, 95% CI = 0.06–0.99, P for interaction = 0.04). Also, our result indicated, there was no interaction between AA genotype and high total oxygen radical absorbance capacity (T-ORAC) and total phenolic intakes on reduce odds of MetS (OR = 0.07, 95% CI = 0.07–1.10, P for interaction = 0.07, OR = 0.58, 95% CI = 0.16–2.07, P for interaction = 0.40) respectively.ConclusionThe results of the present study indicate that high L-ORAC and high H-ORAC intake may modify the elevated odds of MetS in AA genotype of rs1333048 on the 9p21 genetic locus.

Highlights

Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs)
metabolic syndrome (MetS) and its components, including hyperglycemia, hypertension, dyslipidemia and abdominal obesity have been indicated to be strongly associated with oxidative stress; a condition which is characterized by excessive production of reactive oxygen species (ROS) and/or lipid peroxidation, as well as diminished antioxidant protection
We find confounding factors with best fitted model and adjusted its effect of on exposure group, for interaction between rs 1333048 genotype and H-oxygen radical absorbance capacity (ORAC) intakes on odds of MetS, adjusted for sex, age, physical activity and Waist circumference (WC) and for interaction between rs1333048 genotype and Lyophilic oxygen radical absorbance capacity (L-ORAC), total oxygen radical absorbance capacity (T-ORAC) and total phenolic (TP) intakes on odds of MetS, adjusted for sex, age, physical activity and Body mass index (BMI)

Summary

Introduction

Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants have shown to have potential favorable effects on MetS prevention. Metabolic syndrome (MetS) is a growing public health problem worldwide, one which increases the risk of the development and progression of cardiovascular diseases (CVDs) [1]. Previous studies have shown increased production of oxidant biomarkers and decreased levels of antioxidant defense in patients with MetS. Oxidative stress impairment or altered antioxidant status have been suggested as effective keys in the onset of certain chronic diseases such as CVDs, MetS [2]. Oxidative stress seems to be associated with the development of chronic heart diseases (CHDs) and metabolic complications among patients with MetS [3]. Increased oxidative stress underlies the pathophysiology of hypertension [4] and CVDs [5] by directly affecting vascular wall cells and decreases insulin secretion from pancreatic β cells [6]

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