Abstract
Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.
Highlights
PROTEIN-PROTEIN INTERACTIONSIrrepressible maturation of cells and their resistance to apoptosis are the important features of the cancer cells [1]
Cancer cells turned as drug resistance, so anticancer drugs and small molecular inhibitor compounds development consider the key proteins involved in tumorigenesis and the mechanism [76]
The present review focused on the role of Protein-protein interaction (PPI) on development of therapeutics by considering the key proteins involved in tumorigenesis and mechanism
Summary
PROTEIN-PROTEIN INTERACTIONSIrrepressible maturation of cells and their resistance to apoptosis are the important features of the cancer cells [1]. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.
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