Abstract
The interacting effects of fat type and carbohydrate source on the hepatic lipogenic response to starvation-refeeding were studied. Three experiments were conducted using male rats fed ad libitum or starved for 48 hours and refed one of four diets. The diets contained corn or menhaden oil and glucose or sucrose. The activities of NADP-linked glucose 6-phosphate dehydrogenase and malic enzyme were determined as were liver lipid (Experiments 1 and 2) and de novo fatty acid synthesis (Experiment 3). Experiment 1 used Sprague-Dawley rats while experiments 2 and 3 used BHE rats. Rats refed the menhaden oil diets had less of a lipogenic response to starvation-refeeding compared to rats refed the corn oil diets. Sucrose-refed rats had more of an enzyme response and a greater fatty acid synthesis response to refeeding than BHE rats refed either of the menhaden oil diets or the corn oil-glucose diet. The percent increment in these parameters was strain dependent. We conclude that the effectiveness of menhaden oil in decreasing fatty acid synthesis is dependent on the type of carbohydrate in the diet and the genetic character of the animal used.
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