Inter-trial coherence as a measure of synchrony in cervical vestibular evoked myogenic potentials

Abstract

BackgroundCervical vestibular evoked myogenic potentials (cVEMPs) are surface-recorded responses that reflect saccular function. Analysis of cVEMPs has focused, nearly exclusively, on time-domain waveform measurements such as amplitude and latency of response peaks, but synchrony-based measures have not been previously reported. New MethodTime-frequency analyses were used to apply an objective response-detection algorithm and to quantify response synchrony. These methods are new to VEMP literature and have been adapted from previous auditory research. Air-conducted cVEMPs were elicited using a 500 Hz tone burst in twenty young, healthy participants. ResultsTime-frequency characteristics of cVEMPs and time-frequency boundaries for response energy were established. An inter-trial coherence analysis approach revealed highly synchronous responses with representative inter-trial coherence values of approximately 0.7. Comparison with existing methodsInter-trial coherence measures were highly correlated with conventional amplitude measures in this group of young, healthy adults (R2 = 0.91 – 0.94), although the frequencies at which these measures had their largest magnitude were unrelated (R2 =.02). Conventional measures of peak-to-peak amplitude and latency were consistent with previous literature. Interaural asymmetry ratios were comparable between amplitude- and synchrony-based measures. ConclusionsSynchrony-based time-frequency analyses were successfully applied to cVEMP data and this type of analysis may be helpful to differentiate synchrony from amplitude in populations with disrupted neural synchrony.