Abstract
Background: Grading of meningiomas using the World health organization (WHO) Classification of the Central Nervous System criteria currently has an essential role in classification, treatment, prognosis prediction, and research of these tumors. Aims: This is a retrospective study that assessed the interobserver variation between Anatomical Pathologists in grading meningiomas using material obtained from ten resection specimens. The WHO grading system includes different methods, including the mitotic count, the tumor subtypes or the presence of three out of five certain morphological features. This paper focuses on the interobserver variability in the latter method. Methods: Meningiomas that were originally graded based upon mitoses, brain invasion, or morphological subtype were excluded. Ten different Anatomical Pathologists, including two Neuropathologists, who were blinded to the original diagnosis and grade graded the tumors independently.
Highlights
If three out of specific five criteria are interobserver variation between Anatomical Pathologists in grading meningiomas using material obtained from ten resection specimens
Explores the responses of ten pathologists who examined ten cases of meningiomas, where grading variability may occur due to different interpretations of these five criteria
Clinicians and researchers need to understand the difficulty in grading some meningiomas
Summary
If three out of specific five criteria are interobserver variation between Anatomical Pathologists in grading meningiomas using material obtained from ten resection specimens. These five criteria are increased cellularity, different methods, including the mitotic count, the tumor small cells change with high N/C ration, large and subtypes or the presence of three out of five certain prominent nucleoli, patternless or sheet-like growth and morphological features. Methods: Meningiomas that were originally graded based upon mitoses, brain invasion, or morphological subtype were excluded.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
