Abstract
The study aimed to compare three methods for determining total (TF) and total soluble fluorides (TSF) in 5 child formula dentifrices (CFD) using Inter-method reliability (IMR) statistical approach. The methods were direct acid-hydrolysis (DM), the least-time-consuming method; Modified direct acid-hydrolysis with standard-addition method (MDM), ISO 19448:2018 method; and modified Taves acid-HMDS diffusion analysis (TAD), the claimed gold standard method. A significant difference in the mean difference was observed for all methods at all levels (p < 0.001), except DM and TAD for TF (p = 0.622). A proportional bias was discerned in the agreement distribution between DM and TAD for TF (p < 0.001). The ICC analysis identified significant reliability between all measurements, irrespective of the model, measure, and fluoride type (p < 0.001). For TF and TSF, the IMR between DM and TAD was lower than MDM and TAD for consistency/absolute agreement reliability at single/average measures. The reliability measure for DM and MDM was higher than MDM and TAD for TSF, but was lower than MDM and TAD for TF. The ICC measure for DM-TAD was significantly lower than DM-MDM and MDM-TAD (p < 0.05). The ISO 19448:2018 MDM is a reliable test that can be used as an alternative to TAD/DM for determining TF/TSF in CFD.
Highlights
The study aimed to compare three methods for determining total (TF) and total soluble fluorides (TSF) in 5 child formula dentifrices (CFD) using Inter-method reliability (IMR) statistical approach
For total F (TF) and TSF, the IMR between Direct acid‐hydrolysis method (DM) and Taves acid-HMDS diffusion analysis (TAD) was lower than Modified direct acid-hydrolysis with standard-addition method (MDM) and TAD for consistency/absolute agreement reliability at single/average measures
The reliability measure for DM and MDM was higher than MDM and TAD for TSF, but was lower than MDM and TAD for TF
Summary
The study aimed to compare three methods for determining total (TF) and total soluble fluorides (TSF) in 5 child formula dentifrices (CFD) using Inter-method reliability (IMR) statistical approach. A study on child formula dentifrices in Chile found considerably lower TSF as compared to TF in several low-F containing dentifrices, illustrating the presence of insoluble F, whereas those high-F dentifrices with mean F concentration > 1000 ppm had TF similar to the measured TSF5. Considering the results of the previous s tudies[5,6] it is possible that the low-fluoride child dentifrices (400–1000 ppm F) contain significantly less TF and TSF, different from the claims of the manufacturers, which might have further affected its caries-preventive potential. The method is not indicated for all F sources in the dentifrices, especially those with some profluoride compounds
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