Abstract
Inter- and intrasubject variations in drug absorption kinetics were studied in 15 subjects who ingested 975 mg. of aspirin in compressed tablets on two separate occasions. The group included unusually rapid and unusually slow eliminators of salicylate. Average as well as individual absorption data could be described as firstorder processes preceded by a short induction period. The magnitude of variations in rate constants and induction times between subjects and between tests in any one subject has been determined, and the possible existence of consistently slow and rapid drug absorbers has been examined. In vitro dissolution of drug from the dosage form was describable as a first-order process, and a quantitative correlation between in vitro dissolution and in vivo absorption data has been obtained. Acceptance of a given mathematical model, based on average data, as a description of drug absorption and elimination processes is justified only if the model fits the majority of the individual data. It also must be appreciated that considerable inter- and intrasubject variations in rate constants may exist.
Published Version
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