Abstract
The role of this systematic review is to analyse and compare with a meta-analytic approach the outcomes of lobectomy versus intentional segmentectomy in the surgical treatment of stage I non-small cell lung cancer (NSCLC) as reported in the largest studies on the subject published to date. Regarding the results, most of these studies were based on the retrospective data. The size of the cohorts varied from 17 to 11,520 with a total number of 31,684 patients. The pooled hazard ratio was 1.08 (95% CI = 0.97–1.21; p = 0.16). The survival in the lobectomy group was not superior to patients treated with intentional segmentectomy in stage I NSCLC. A large numbered, prospective, randomised trials are needed to assess the feasibility of intentional segmentectomy and its oncologic value in this group of patients, in order to dissolve the questions raised by retrospective data.
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