Abstract
Intention to Treat Analysis: Are We Really Doing It?: Reply
Highlights
This reply addresses a response to an article my colleagues and I wrote on the subject of the principle of intentionto-treat (ITT), which has become widely accepted for the analysis of controlled clinical trials [1]
210 consenting female patients considered for total thyroidectomy were randomly assigned to two groups equal in size (n = 105): visual inspection of the external branch of the superior laryngeal nerve (EBSLN) and recurrent laryngeal nerve (RLN) versus this visual inspection plus EBSLN and RLN neural monitoring
The secondary outcomes included anatomical variability of the EBSLN according to the Cernea classification, and changes in postoperative voice performance during a six-month follow-up
Summary
This reply addresses a response to an article my colleagues and I wrote on the subject of the principle of intentionto-treat (ITT), which has become widely accepted for the analysis of controlled clinical trials [1]. A few missing outcomes do not cause a problem, if the power of the trial is not lost by a reduced total sample size, and if loss to follow-up is not related to a patient’s response to treatment.
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