Intensive treatment of ovarian hyperstimulation syndrome. Clinical guidelines (treatment protocol)

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a systemic disease that develops as a result of activation of the production of vasoactive mediators by the ovaries against the background of stimulation of superovulation. OHSS is characterized by an increase in the permeability of the capillary walls, which leads to the release of intravascular fluid into the extravascular space, its accumulation in the third space and hemoconcentration. Severe OHSS is characterized by the risk of thrombosis, impaired liver function, kidney function and the occurrence of adult respiratory distress syndrome (ARDS). In these clinical guidelines, the main provisions for the prognosis, diagnosis, prevention and intensive care of OHSS are presented, including the principles of treatment of intra-abdominal hypertension (IAH).