Intensity modulated radiation therapy (IMRT) may reduce the oesophageal toxicity of hypofractionated accelerated 3-D radiation for non small cell lung carcinoma

Abstract

7233 Background: Several groups are assessing the feasibility of increasing the radiobiological impact of 3-D radiation for NSCLC by using high dose per fraction dose escalation. We report the most mature data of any trial using 3Gy /fraction (72 Gy/24 fractions). Methods: 30 pts with NSCLC with KPS>70% and wt loss =25 Gy (V25) and the max. dose to the cord was < 61%. No oesophageal dose limits were used. Results: 8 CR and 11 PR in 27 evaluable pts. Median time to local progression, progression and survival: 18.6, 17.3 and 12.6 months. No grade-4 acute toxicity occurred. 2 pts had grade-3 acute oesophageal toxicity and 1 pt a grade 3 acute lung toxicity. 26 pts were evaluable for long-term toxicity (median follow-up 9.5 months). Late grade-1 lung toxicity occurred in 5 pts. Late oesophageal toxicity was clinically...