Abstract
Objective To verify the efficiency of nasopharyngeal carcinoma(bIPC) treated with intensity modulated radiation therapy(IMRT) and to observe the acute and late normal tissue toxicities. Methods Total of 40 cases of primary and recurrent nasopharyngeal carcinoma were treated with IMRT The target volume was described as : the gross tumor volume of the nasopharynx (GTVnx),the cervical lymph node (GTVnd), the clinical volume (CTV1), and the clinical volume (CTV2), respectively.The prescribed dose to the GTVnx, GTVnd, CTV1,CTV2 were 68 -74,60 -66,60,54 Gy,respectively. Total fraction was 30.32 patients had radiotheraphy combined with cisplatin based chemotherapy, whereas 8 patients were treated with radiotheraphy alone. Results The mean doses of GTVnx, GTVnd, CTV1, CTV2 were 72.40,67.83,60.25,64.85. With a median follow-up of 9 months, the local regional progression - free rate was 100%, one patient had metastasis in liver and lung. Conclusion Simultaneous modulated accelerated radiation therapy yields better dose distribution and acceptable toxicity than the traditional radiotherapy in beth early and advanced stage nasopharyngeal carcinoma. The preliminary clinical result is encouraging. Key words: Nasopharyngeal neoplasms; Intensity modulated radiation therapy; Prognosis
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