Intelligent photothermal treatment method based on photoacoustic and photothermal probe assistance

Abstract

As a non-invasive, targeted and non-radioactive technology applied to tumor treatment, photothermal therapy is increasingly used in the clinical treatment of tumors due to its high cure rate and few side effects. In order to obtain a better photothermal treatment effect in the actual treatment process, the temperature distribution of the tissue to be treated must be monitored and controlled to prevent unnecessary tissue damage caused by the treatment. Therefore, the photothermal probe and precise control of the treatment temperature become the key to solving the problem. In this paper, a nanoprobe with strong photoacoustic and photothermal properties in one area of near-infrared is designed. At the same time, a photothermal treatment system is designed and combined with nanoprobe for research. This study designed human tissue simulation experiments and found that compared to the case without probe assistance, the photothermal therapy system based on photoacoustic and photothermal probe assistance can achieve temperature control with a temperature error of 1°C , and the temperature control adjustment time has been shortened by 40%, and the overtreatment injury has also been effectively suppressed. More importantly, it is possible to greatly reduce the complexity of the photothermal treatment process in practical applications without the artificial control of continuous laser power. The experimental result shows that the intelligent photothermal treatment method based on the photoacoustic and photothermal nanoprobe is a feasible candidate for tumor treatment and has a good application prospect in the field of tumor treatment.