Abstract
ObjectiveTo evaluate the success rate of the National newborn screening program in maintenance of intelligent quotient (IQ) of children with congenital hypothyroidism in Iran.DesignRetrospective cohort study.MethodsThe IQ scores, in three subsets of verbal, non verbal (Performance) and full scale IQ, of 240 children diagnosed with Transient congenital hypothyroidism (TCH) and Permanent congenital hypothyroidism (PCH), from 5 provinces in 5 different geographical areas of Iran, were measured at the age of 6 years using revised Wechsler pre school and primary scale of intelligence and compared with 240 healthy children. We used independent sample t test and two-way ANOVA for data analysis.ResultsMean of verbal, performance, and full scale IQ scores were lower in the CH cases (permanent and transient) than the control group. Most of the IQ differences in two studied groups related to the PCH cases (P=0.005). Mean difference of IQs between children in the two groups in Yazd province (center of Iran) was higher than other provinces, and they also had significantly lower IQ than their control (healthy) children (P=0.001). No treated child had IQ<70.ConclusionAlthough mean IQs of CH children was lower than their controls, IQ of all treated CH cases were close to the healthy children.
Highlights
Mean intelligence quotient (IQ) of Congenital hypothyroidism (CH) children was lower than their controls, IQ of all treated CH cases were close to the healthy children
The incidence of CH is different among neonates of various countries of the world and ranges from 1:2000 to 1:4000 [2,3,4,5,6], the incidence of CH in different areas of Iran is reported to vary from 1:400 to 1:1000 [7,8]
In Iran, a National program of neonate screening was established from 2004-2005 [9]. In this program, thyroidstimulating hormone (TSH) is measured as a primary test, and positive tests are confirmed by serum thyroxine (T4)
Summary
The IQ scores, in three subsets of verbal, non verbal (Performance) and full scale IQ, of 240 children diagnosed with Transient congenital hypothyroidism (TCH) and Permanent congenital hypothyroidism (PCH), from 5 provinces in 5 different geographical areas of Iran, were measured at the age of 6 years using revised Wechsler pre school and primary scale of intelligence and compared with 240 healthy children. We used independent sample t test and two-way ANOVA for data analysis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
