Abstract
Collective motion is a fascinating example of coordinated behavior of self-propelled objects, which is often associated with the formation of large scale patterns. Nowadays, in vitro gliding assay is being considered a model system to experimentally investigate various aspects of group behavior and pattern formation by self-propelled objects. In this work, we have demonstrated the collective motion of kinesin driven microtubules by regulating mutual interaction among the gliding microtubules, by employing depletion force among them. Proper regulation of the mutual interaction among the gliding microtubules through employment of the depletion force was found to allow the exhibition of collective motion and stream pattern formation by microtubules. We also discuss how collectively moving microtubule on kinesin coated elastomer substrate response to external stimuli such as mechanical stresses.
Highlights
Collective motion is a common display of coordinated behaviour which emerges from moving objects such as animal, birds, fishes, insects, bacteria, cells and self-propelled particles
Biomolecular motor systems such as Factin/myosin and microtubule/dynein have been used as model systems for experimentally demonstrating collective motion of self-propelled objects by employing them in the in vitro gliding assay where cytoskeletal filaments are driven by biomolecular motors immobilized on a surface in the presence of adenosine triphosphate (ATP) [1,2,3,4,5,6]
We have regulated the interaction of gliding microtubules by employing depletion force among them which is an attractive interaction known to work between colloidal particles or macromolecules suspended in polymer solution such as methylcellulose (MC) or polyethylene glycol (PEG)
Summary
Collective motion is a common display of coordinated behaviour which emerges from moving objects such as animal, birds, fishes, insects, bacteria, cells and self-propelled particles. Biomolecular motor systems such as Factin/myosin and microtubule/dynein have been used as model systems for experimentally demonstrating collective motion of self-propelled objects by employing them in the in vitro gliding assay where cytoskeletal filaments are driven by biomolecular motors immobilized on a surface in the presence of adenosine triphosphate (ATP) [1,2,3,4,5,6].
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