Abstract
Background Multi drug resistance (MDR) in gram negative bacilli (GNB) is an increasing global problem, which is often due to the acquisition of resistance genes from a shared pool. In MDR isolates, integrons-resistant gene cassettes, together with its accessory genetic elements (integrase) may be found in complex conglomerations on plasmids or on the chromosome and are widely acknowledged for their role in conferring MDR phenotype. Hence, the present study was done to evaluate the usefulness of integrase gene PCR as a surrogate marker for MDR in GNB.
Highlights
Multi drug resistance (MDR) in gram negative bacilli (GNB) is an increasing global problem, which is often due to the acquisition of resistance genes from a shared pool
The present study was done to evaluate the usefulness of integrase gene PCR as a surrogate marker for MDR in GNB
A total of 39 isolates were positive for either class I or class II integrons
Summary
Integrons as surrogate marker for multi drug resistance in gram negative bacilli Gopalakrishnan Kaushik1*, K Arunkumar, G Sivakumar, R Rajasomasundharam, Padma Krishnan. From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. 20-22 January 2012
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