Abstract
Integrins Minireview Series
Highlights
Integrins constitute a large family of ␣ heterodimeric cell surface, transmembrane proteins that recognize a large number of extracellular ligands through a metal ion-dependent interaction
Additional important roles for integrins in immune, inflammatory and infectious disease have been revealed by in vitro and gene ablation studies. The minireviews in this and following issues update our understanding of integrins in four general areas: structure and ligand binding
It is clear that binding of integrins to ligands is regulated by intracellular signaling, so-called “inside-out” signaling
Summary
Integrins constitute a large family of ␣ heterodimeric cell surface, transmembrane proteins that recognize a large number of extracellular ligands through a metal ion-dependent interaction. Their biological and medical importance is underscored by inherited diseases causing bleeding (Glanzmann’s thromasthenia) and infection (leukocyte adhesion deficiency). Additional important roles for integrins in immune, inflammatory and infectious disease have been revealed by in vitro and gene ablation studies.
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