Abstract

Integrins Minireview Series

Highlights

  • Integrins constitute a large family of ␣␤ heterodimeric cell surface, transmembrane proteins that recognize a large number of extracellular ligands through a metal ion-dependent interaction

  • Additional important roles for integrins in immune, inflammatory and infectious disease have been revealed by in vitro and gene ablation studies. The minireviews in this and following issues update our understanding of integrins in four general areas: structure and ligand binding

  • It is clear that binding of integrins to ligands is regulated by intracellular signaling, so-called “inside-out” signaling

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Summary

Introduction

Integrins constitute a large family of ␣␤ heterodimeric cell surface, transmembrane proteins that recognize a large number of extracellular ligands through a metal ion-dependent interaction. Their biological and medical importance is underscored by inherited diseases causing bleeding (Glanzmann’s thromasthenia) and infection (leukocyte adhesion deficiency). Additional important roles for integrins in immune, inflammatory and infectious disease have been revealed by in vitro and gene ablation studies.

Results
Conclusion

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