Abstract
increased when siRNA was complexed with PEI. The amount of siRNA adsorbed generally appeared greater in ePET than in PTFE fabrics. Repeated dipping of ePET in siGLO Red/PEI solution significantly increased siRNA adsorption vs single dipping. Conclusions: siRNA adsorption to ePET and PTFE surfaces is significantly increased if the siRNA is complexed with PEI. Preliminary data in this study suggest that siRNA adsorbs better to ePET than PTFE. Further, repeated dipping of ePET additionally increased adsorption of siRNA to fabric. Thus, coating of ePET with siRNA/PEI may be a method to improve graft patency.
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