Abstract

Evolution as engineering, Richard C. Lewontin. Part 1 Computational biology: analysis of bacteriophage T4 based on the completed DNA sequence, Elizabeth Kutter the identification of protein functional patterns, Temple F. Smith et al comparative genomics - a new integrative biology, Robert J. Robbins on genomes and cosmologies, Antoine Danchin. Part 2 Regulation, metabolism and differentiation - experimental and theoretical integration: a kinetic formalism for integrative molecular biology - manifestation in biochemical systems theory and use in elucidating design principles for gene circuits, Michael A. Savageau genome analysis and global regulation in escherichia coli, Frederick C. Neidhardt feedback loops - the wheels of regulatory networks, Rene Thomas integrative representations of the regulation of gene expression, Julio Collado-Vides eukaryotic transcription, Thomas Oehler and Leonard Guarente analysis of complex metabolic pathways, Michael L. Mavrovouniotis where do biochemical pathways lead?, Jack Cohen and Sean H. Rice gene circuits and their uses, John Reinitz and David H. Sharp fallback positions and fossils in gene regulation, Boris Magasanik the language of the genes, Robert C. Berwick.

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