Abstract
Although obstructive sleep apnea (OSA) has been clinically reported to be associated with acute coronary syndrome (ACS), the pathogenesis between the two is unclear. Herein, we analyzed and screened out the prospective molecular marker. To explore the candidate genes, as well as signaling cascades involved in ACS related to OSA, we extracted the integrated differentially expressed genes (DEGs) from the intersection of genes from the Gene Expression Omnibus (GEO) cohorts and text mining, followed by enrichment of the matching cell signal cascade through DAVID analysis. Moreover, the MCODE of Cytoscape software was employed to uncover the protein–protein interaction (PPI) network and the matching hub gene. A total of 17 and 56 integrated human DEGs in unstable angina (UA) and myocardial infarction (MI) group associated with OSAs that met the criteria of |log2 fold change (FC)|≥ 1, adjusted P < 0.05, respectively, were uncovered. After PPI network construction, the top five hub genes associated with UA were extracted, including APP, MAPK3, MMP9, CD40 and CD40LG, whereas those associated with MI were PPARG, MAPK1, MMP9, AGT, and TGFB1. The establishment of the aforementioned candidate key genes, as well as the enriched signaling cascades, provides promising molecular marker for OSA-related ACS, which will to provide a certain predictive value for the occurrence of ACS in OSA patients in the future.
Highlights
Obstructive sleep apnea (OSA) has been clinically reported to be associated with acute coronary syndrome (ACS), the pathogenesis between the two is unclear
We have studied candidate genes and signal pathways involved in ACS related to OSA, which will help provide a certain predictive value for the occurrence of ACS in OSA patients in the future
587 differentially expressed genes (DEGs) were selected from unstable angina (UA) samples and normal controls in the
Summary
Obstructive sleep apnea (OSA) has been clinically reported to be associated with acute coronary syndrome (ACS), the pathogenesis between the two is unclear. The establishment of the aforementioned candidate key genes, as well as the enriched signaling cascades, provides promising molecular marker for OSA-related ACS, which will to provide a certain predictive value for the occurrence of ACS in OSA patients in the future. Compared with the general population, prevalence of OSA is higher in acute coronary syndrome (ACS) patients and ranges from 36 to 63% across various e thnicities[13]. High-throughput sequencing techniques such as molecular diagnosis, prognosis estimation, as well as drug target discovery (which can be employed to assess the gene expression differences, as well as the variable splicing variation), are gradually considered to have important clinical significance in disease research. MI Gene name KRI1 ATXN7L1 PURAC2orf[48] SLC35A4 LOC101928651 BPTF MTMR2 NDC1 LALBA TBX19 STS F10 SSX3 RAB11FIP4 GPRC5C SRI LDB2 P3H2 LALBA
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