Abstract
The 12 weeks of treatment with Rosa Roxburghii Tratt Juice can regulate Dyslipidemia by improving intestinal microbiota disorders and related metabolomics disorders, and their related metabolites might inhibit glycolytic and regulate energy metabolism disorder to improve the states of Dyslipidemia. • Rosa Roxburghii Tratt juice can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders. • Rosa Roxburghii Tratt juice partially improved dyslipidemia and obesity induced by HFD by increasing Roseburia, Bifidobacterium and reducing Coprobacillus, Dorea levels, as well as reductions in cystine, glyceric acid, palmitoleic acid, propionic acid, and succinic acid-related levels. The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 weeks of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight. RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile analysis of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyses suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 weeks of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders.
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