Abstract
This study aims to compare reported proteins expressed in controls and patients with SS in tear, saliva and serum from proteins identified in papers published between 2000 and 2020, to obtain a systematic comparison of proteins expressed in SS patients to find proteins that can be used as biomarkers in SS. Differentially expressed proteins from Sjögren's patients identified in the studies were classified by body fluid (saliva, serum, tear and saliva from healthy patients). Protein pairing was carried out in RStudio, using the previously created data framework, PANTHER and REACTOME 7.O. were used to explore the type of proteins associated with SS and enriched metabolic pathways. Five differentially expressed proteins were found in saliva, tear, and serum. Finally, this study suggests antithrombin III and E-cadherin. as biomarkers in SS, because these proteins are differentially expressed in plasma, blood, and tear, and that neutrophil degranulation pathway as a target for SS.
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