Abstract
Presented in this paper is an integrated approach of computer aided product development, process design and operation analysis based on a kilo-plant. It supports to find solutions for the complicated technical problems in chemical product development, as well as in the design and operation of the manufacture processes. As a research platform, the kilo-plant was specifically designed for batch manufacture of fine and specialties chemicals in kilogram-scale. The characteristics of product synthesis, process operation, and product quality control are investigated in coupled with computer aided monitoring, online modeling, simulation and operation optimization. As a consequence, it provides a systematic methodology through the integration of chemical product discovery, process design and operation, which aims at responding to the rapid changes in the marketplaces to the new products demands.
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