Abstract
Cefquinome is a fourth generation cephalosporin with antimicrobial activity against gram negative and gram positive bacterial species, including Staphylococcus aureus. The aim of our study was to observe the ex-vivo activity of cefquinome against Staphylococcus aureus strains by using bovine serum from intravenously treated cattle. Cefquinome kinetics were measured by liquid chromatography and UV detection. In vitro post antibiotic effects (PAEs) and mutant prevention concentrations were determined with S. aureus strain ATCC 12598. Cefquinome exhibited time-dependent killing and produced in vitro PAEs increasing with concentration and time of exposure. A pharmacokinetic-pharmacodynamic model was established to simulate the efficacy of cefquinome for different dosage regimens. A dosage of 2 mg/kg every 12 h for 3 days was expected to reach a bactericidal activity against S. aureus in case of septicemia.
Highlights
Staphylococcus aureus is a gram positive bacteria, responsible for many animal and human diseases
Pharmacokinetics of Cefquinome No adverse reactions were observed after intravenous drug administration
Plasma concentration of cefquinome was best fitted with a two-compartment model (Table 1)
Summary
Staphylococcus aureus is a gram positive bacteria, responsible for many animal and human diseases. It can cause an extensive variety of infections from skin and soft tissue infections to septicemia. If it is not treated efficiently, the sepsis can produce inflammatory response, organ dysfunction syndrome, shock, and death (Fecteau et al, 2009; Fluit, 2012). Bacteremia was observed during the neonatal period in 20–30% of diarrheic calves. The bacteria isolated included Escherichia coli, Salmonella spp, Campylobacter spp, Klebsiella spp., and Staphylococcus spp (Raboisson et al, 2010). The mortality rate will be high (Gordon, 1998)
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