Integration of Metabolic Knowledge for Genome‐Scale Metabolic Reconstruction

Abstract

Genome-scale metabolic reconstruction is the ultimate goal of system biologists for finding out the genotype-phenotype relationship. For achieving this purpose, we need enough knowledge about the metabolic pathways and genome annotation. During the present study, we aim to describe the foundational concepts, central to omics data, model formulation, history, method and applications of metabolic network reconstruction as well as some related sources. In section 1.2, we describe omics data and high-throughput technologies for gaining these data. In section 1.3, we present different ways for metabolic network modeling. In section 1.4, we summarize the history of genome-scale modeling as one of the most important method for metabolic network modeling. In sections 1.5 and 1.6, we elucidate how genome-scale metabolic models could be generated and what are their applications. Finally, in section 1.7, we review biochemical pathways and genome annotation databases.