Abstract
Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.
Highlights
Biomaterials to be used in dental and orthopedic applications should exhibit the ability to form a strong bond with bone tissue and to promote bone growth
An importantthaisspbeecht ainvitohreisutsheeoZf eptaarptioctleesntaiasldorfutghecaprarrietircsleiss,iwtshciacphaccaintyptroormemoteaitnhe repealing or the homogenous and datistrpaecrtsieoninolfiqthueidpeanrtviicrloens minednitfsf.eOrennet oefntvhieropnrmopeenrttsi.esThtheaZt iemtappaocttsenthtiiasl of the composite behavior is the Zemtaicproostpenhteiraelsowf atshe−p14a.r3t0ic±les1,.3w3hmicVh,owr hthiceh indicates that the attraction of the pafarbtircilceasteind dmificferoresnptheenrevsirsohnomulednntso.tTthenedZteotaagpgoltoemnteiaral toefitnhaeqcuoemoupsoseintevironments similar
The composite microspheres exhibited an average diameter of 2.10 ± 0.27 μm, spherical uniform shape and a semi-homogeneous distribution under certain mesoporous bioactive glass nanoparticles (MBGN) concentrations
Summary
Biomaterials to be used in dental and orthopedic applications should exhibit the ability to form a strong bond with bone tissue and to promote bone growth. Some authors have reported the rapid exchange of ions between the MBGN and the aqueous medium, which may result in a rapid and undesired increase of the pH of the medium [11,12]; this could make the biocompatibility and assimilation of MBGN in biological environments difficult Another possible cause of these effects could be due to the interaction presented between nanoparticles and cells, in which the contact with the cell membrane is different than with devices of bigger sizes; this can be considered an important cause of the side effects observed.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
