Abstract
A curved D-type optical fiber sensor (OFS) combined with a microfluidic chip is proposed. This OFS, based on surface plasmon resonance (SPR) of the Kretchmann’s configuration, is applied as a biosensor to measure the concentrations of different bio-liquids such as ethanol, methanol, and glucose solutions. The SPR phenomenon is attained by using the optical fiber to guide the light source to reach the side-polished, gold-coated region. Integrating this OFS with a polymethylmethacrylate (PMMA)-based microfluidic chip, the SPR spectra for liquids with different refractive indices are recorded. Experimentally, the sensitivity of the current biosensor was calculated to be in the order of 10−5 RIU. This microfluidic chip-integrated OFS could be valuable for monitoring subtle changes in biological samples such as blood sugar, allergen, and biomolecular interactions.
Highlights
The surface plasmon resonance (SPR) phenomenon occurs as the consequence of exciting a surface-bound electromagnetic wave at the interface between a metal and a transparent material.Biosensors based on this technique have been designed and constructed for label-free and real-time detection of biomolecular interactions [1,2,3,4,5,6]
The results indicated that the optical loss of the Gaussian guided mode could be made very small by tuning the thickness of the dielectric layer and that the refractive-index resolution for aqueous analytes is 1 × 10−4 RIU
The results suggest that this microfluidic chip-integrated optical fiber sensor (OFS) can serve as a biosensor for sensitive, label-free, real-time, and in-situ monitoring of biomolecular interactions
Summary
The surface plasmon resonance (SPR) phenomenon occurs as the consequence of exciting a surface-bound electromagnetic wave at the interface between a metal and a transparent material. Biosensors based on this technique have been designed and constructed for label-free and real-time detection of biomolecular interactions [1,2,3,4,5,6]. The grating-coupled SPR takes place when the light diffracted by the grating has different orders with at least one inducing SPR [14,15,16]
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