Abstract
We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
Highlights
We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot repository
Active Bacterial Core surveillance (ABCs) is a network of state health departments, academic institutions, and local collaborators funded by the Centers for Disease Control and Prevention (CDC)
This network conducts populationbased surveillance for invasive bacterial pathogens, including encapsulated bacteria Haemophilus influenzae, Neisseria meningitides, and Streptococcus pneumoniae [2]; the Minnesota Department of Health has been involved in ABCs since 1995
Summary
Active Bacterial Core surveillance (ABCs) is a network of state health departments, academic institutions, and local collaborators funded by the Centers for Disease Control and Prevention (CDC). This network conducts populationbased surveillance for invasive bacterial pathogens, including encapsulated bacteria Haemophilus influenzae, Neisseria meningitides, and Streptococcus pneumoniae [2]; the Minnesota Department of Health has been involved in ABCs since 1995. We cross-referenced ABCs data to the state’s nDBS repository to identify nDBSs from Minnesota ABCs case-patients and controls. ABCs data from casepatients with parental consent and from case-patients who did not respond after 2 successive mailings were included in the study. Genomic DNA was amplified from 3-mm punches of 1/2′′ nDBSs by using multiple displacement techniques [8]
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