Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Rajasree Menon,Kristina N Blank,Annapurna Pamreddy,Nancy Wang,Katherine R Tuttle,Stewart H Lecker,Krzysztof Kiryluk,Ninive C Conser,Dana C Crawford,Ricardo Melo Ferreira,Frederick Dowd,Stephanie M Grewenow,Keith Brown,Yougqun He,Kun Zhang,Christopher Y Lu,Jack Bebiak,Yuguang Xiong,Ning Shang,Daria Barwinska,Orson W Moe,Kenneth W Dunn,Nichole Jefferson,Ian H De Boer,Chrysta Lienczewski,Parmjeet Randhawa,Guanshi Zhang,Michael T Eadon,Yury Goltsev,Jeffrey B Hodgin,Steve Bogen,Richard Montellano,Cijang He,Richard Knight,Pierre C Dagher,Joseph Ardayfio,Victoria M Blanc,James C Williams,Hongping Ye,Chirag R Parikh,John A Kellum,Marcelino Rivera,Carissa Vinovskis,Robyn L Mcclelland,James Winters,Catherine E Campbell,Dianna Sendrey,Steven Menez,Jane Nguyen,Robert Koewler,Paul J Lee,Mia R Colona,Jessica Lukowski,Heather Ascani,Tanima Arora,Christy Stutzke,Leslie Cooperman,Sylvia E Rosas,Neil Roy,Mark Williams,Evren U Azeloglu,Jonathan Himmelfarb,Rachel Sealfon,Samir Parikh,Vivette D D’Agati,Joseph P Gaut,Karla Mehl,R Tyler Miller,Astrid Weins,Avi Rosenberg,Sean Eddy,Timothy A Sutton,Glenda V Roberts,Sean D Mooney,Theodore Alexandrov,William S Bush,Michael J Ferkowicz,Roy Pinkeney,Andrew S Bomback,Daniel E Hall,Pietro A Canetta,Kayleen Williams,Satoru Kudose,Rita R Alloway,Katherine J Kelly,Nir Hacohen,Raghavan Murugan,Ugochukwu Ugwuowo,Sanjay Jain,Jinghui Luo,Leal Herlitz,Charles E Alpers,Blue B Lake,Seth Winfree,Olivia Balderes,Kumar Sharma,Laurence H Beck,E Steve Woodle,Becky Steck,Lynda Hayashi,Paul M Palevsky,Asra Kermani,Matthias Kretzler,Ravi Iyengar,Mitchell Tublin,Jens Hansen,Stephen Daniel,S Susan Hedayati,Jonas Carson,John Saul,Shweta Bansal,Anitha Vijayan,Andrew N Hoofnagle,Taneisha Campbell,George Oliver,Robert D Toto,Patrick Boada,John P Shapiro,Anna Shpigel,Gearoid M Mcmahon,Stuart J Shankland ,Matthew R Rosengart ,Simon J Craddock Lee ,Paul Hoover ,Brad H Rovin ,John F O’toole ,Mark P Aulisio ,Dennis G Moledina ,John R Sedor ,Isaac E Stillman ,Garry P Nolan ,Adam B Wilcox ,Ying‐Hua Cheng ,Sushrut S Waikar ,Jennifer A Schaub ,Zoltán Lászik ,Tarek M El‐Achkar ,Kamalanathan K Sambandam ,Olga G Troyanskaya ,Dušan Veličković ,Ljiljana Paša‐Tolić ,Helmut G Rennke ,Laura Mariani ,Petter Bjornstad ,José Torrealba ,Miguel A Vázquez ,Ellen L Palmer ,Michele Elder ,Harold S Park ,Sharon B Bledsoe ,Paul S Appelbaum ,F Perry Wilson ,Tara K Sigdel ,Ulysses Balis ,Emilio D Poggio ,Chris Park ,Ashveena Dighe ,Edgar A Otto ,Minnie M Sarwal ,Agustin Gonzalez‐Vicente ,Manjeri A Venkatachalam ,Christopher Anderton ,Jonathan Barasch ,Celia P Corona‐Villalobos ,Stacey E Jolly

doi:10.1016/j.kint.2022.03.011

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Rajasree Menon, Kristina N Blank + Show 163 more

Open Access

https://doi.org/10.1016/j.kint.2022.03.011

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Journal: Kidney International	Publication Date: Mar 23, 2022
Citations: 11	License type: publisher-specific-oa

Affiliation: University of Michigan–Ann Arbor, University of Washington, University of California, San Diego, Johns Hopkins Medicine, Johns Hopkins University, Columbia University, Washington University in St. Louis

#Kidney Precision Medicine Project #Acute Kidney Injury + Show 8 more

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Abstract

Acute kidney injury (AKI) induces a broad range of clinically significant perturbations in kidney morphology and function. Insights into the molecular and cellular basis governing a clinical-pathologic course are limited by the availability of molecular maps of healthy and injured kidney cells. The Kidney Precision Medicine Project (KPMP) and the Human Biomolecular Atlas Project (HuBMAP) have generated a comprehensive molecular atlas of the kidney from more than 400,000 cells that define healthy and injured cell types and states in AKI and chronic kidney disease.

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