Abstract
A simultaneous multimodality imaging system combining photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence microscopy (FM) was developed, and its performance and safety for ocular imaging was validated on rabbit eye in vivo. Angiogenesis and bleeding can be selectively shown by label free PAM with laser fluence at only 1% of the ANSI safety limit. OCT imaging allows for visualization of the different retinal layers with high axial resolution. The leakage of neovascularization can be verified with FM. The safety of PAM was evaluated by comprehensive longitudinal follow-up with ocular imaging methods, electrophysiology, histology, immunohistochemistry, and electron microscopy.
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