Abstract
BackgroundMarbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it’s in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. A series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with P. multocida type B, serotype 2.ResultsThe ratio of the 24 h area under the concentration-time curve divided by the minimum inhibitory concentration (AUC24TCF/MIC) was the best PK/PD index correlated with the in vivo antibacterial effectiveness of marbofloxacin (R2 = 0.9279). The AUC24TCF/MIC necessary to achieve a 1-log10 CFU/ml reduction and a 3-log10 CFU/ml (90% of the maximum response) reduction as calculated by an inhibitory sigmoid Emax model were 13.48 h and 57.70 h, respectively.ConclusionsMarbofloxacin is adequate for the treatment of swine infected with P. multocida. The tissue-cage model played a significant role in achieving these PK/PD results.
Highlights
Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida
The protein binding of marbofloxacin in pig serum and tissue-cage fluid (TCF) were 52.90% and 47.89% respectively and these values were independent of concentration in the range of 0.05 ~ 2 μg/mL
We found an AUC24TCF/MIC value of 100.25 h (2.5 mg/kg) that was lower than the reported value in plasma in piglets (264.10 h) [28]
Summary
Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it’s in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. P. multocida is a widespread pathogen that inhabits mucosal surfaces and upper respiratory tracts of clinically healthy animals [6]. It is the causative agent of fowl cholera in poultry, atrophic rhinitis in swine and hemorrhagic septicemia in buffalo and cattle [7,8,9,10]. It plays a major role in pneumonia in swine and ruminants as an opportunistic pathogen [11]
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