Integrated approaches to the treatment of pain syndrome in the patients with drug addiction

Abstract

Introduction Pain syndrome is integral acute sign of drug addiction at psychoactive substance deprivation and is a severe urgent state. Objectives and aims To work out integrated approaches to pain syndrome cessation with combined pharmacotherapy and non-pharmaceutical methods. To study dynamics of pain syndrome reduction at application of the developed methods. Methods One hundred and eighty-nine opioid addicts (cessation state) were examined. The treatment efficiency was evaluated with visual analogue scale; Roland-Morris questionnaire; pain numeric rating scale. Results Four innovative options of modified therapy for pain authorized with the patents of Ukraine were proposed (with membrane plasmapheresis, medical electrophoresis, laser therapy and standard pharmacotherapy): – pain syndrome cessation in opioid addicts is provided with Tramadol (up to 600mg i/m), at intravascular laser hemotherapy (wavelength 0.63mcm, power 2mW, 30–40min exposure, 3–4 days course); – recurrent deprivation pain syndrome cessation is realized by membrane plasmapheresis with intravascular laser blood irradiation and i/m 1.0mL Ketanov solution 2–3 days; – pain syndrome treatment in drug and alcohol addicts is provided with Analgin and Sibazon by electrophoresis, current 1.5–5mA, exposure 25–30min, 1–2 procedures daily; – pain syndrome cessation in drug addicts is performed by injection of 0.5% Seduxen solution (up to 4.0mL), paracetamol – (up to 0.4g), 10% solution of sodium caffeine benzoate – 1.0–2.0mL subcutaneously, at night – 0.5% seduxen 2.0–4.0mL, paracetamol – 0.2–0.4g. Conclusions Monitoring and statistical processing data proved that the proposed methods give 1.5–2-fold growth in efficiency of treatment for pain syndrome in drug addicts.