Integrase inhibitors: current protagonists in antiretroviral therapy.

Abstract

Since HIV was identified as the etiological agent of AIDS, there have been significant advances in antiretroviral therapy (ART)that hasreduced morbidity/mortality. Still, the viral genome's high mutation rate, suboptimal ARTregimens, incomplete adherence to therapyand poor control of the viral loadgenerate variants resistant to multiple drugs. Licensing over 30anti-HIV drugs worldwide, including integrase inhibitors, has marked a milestone since they are potent and well-tolerated drugs. In addition, they favor a faster recovery of CD4+ T cells. They also increase the diversity profile of the gut microbiota and reduce inflammatory markers. All of these highlight the importance of including them in different ART regimens.