Abstract
Aim. To assess the prognostic value of the integral assessment using various modern methods for diagnosing congestion in patients hospitalized with acute decompensated heart failure (ADHF).Material and methods. This single-center prospective study included 165 patients with ADHF. All patients underwent a standard clinical and paraclinical examination, including assessing NT-proBNP levels, lung ultrasound B-lines, liver transient elastography, bioelectrical impedance vector analysis (BIVA) at admission and discharge. To assess clinical congestion, the Heart Failure Association consensus document scale was used. Long-term clinical outcomes were assessed by telephone survey 1, 3, 6, 12 months after discharge. As an end point, the allcause mortality and readmissions were estimated.Results. In patients hospitalized with ADHF, at discharge, differences were found in the incidence of residual congestion according to certain paraclinical methods — from 22 to 38%, subclinical — from 14,5 to 27%. When using the integral assessment of stagnation, the incidence of residual and subclinical congestion was 53,6% and 35%, respectively. Patients with residual congestion had more severe symptoms of congestion, compared with those with subclinical congestion. Patients in whom congestion was detected by 4 methods, in contrast to those by 1, 2, and 3 methods, had worse clinical and paraclinical parameters. There was a significant increase in the risk of all-cause mortality and readmission in the presence of congestion, identified by 3 (hazard ratio, 9,4 (2,2-40,6); p<0,001) and 4 methods (hazard ratio, 15,2 (3,3-68,1); p<0,001).Conclusion. For patients hospitalized with ADHF, integral assessment of residual and subclinical congestion at should be performed at discharge. The introduction of an integral assessment of congestion into routine practice will allow to identify a group of patients with more unfavorable prognostic characteristics in relation to the risk of death and readmissions, as well as to intensify drug therapy and followup at the outpatient stage.
Highlights
РАН, зав. кафедрой внутренних болезней с курсом кардиологии и функциональной диагностики, зав. кафедрой внутренних болезней, кардиологии и клинической фармакологии ФПК МР, ORCID: 0000-0002-5873-1768, Толкачева В
Santarelli S, Russo V, Lalle I, et al Usefulness of combining admission brain natriuretic peptide (BNP) plus hospital discharge bioelectrical impedance vector analysis (BIVA) in predicting 90 days cardiovascular mortality in patients with acute heart failure
Summary
Всем пациентам проводили стандартное физическое обследование, лабораторно-инструментальные исследования, включая NT-proBNP, УЗИ легких, НЭМ, БИВА при поступлении и при выписке. Для оценки статуса гидратации выполняли БИВА (АВС-01 “Медасс”). Количест вен ные переменные описывали как среднее арифмети ческое значение (М) и стандартное отклонение среднего значения (SD) (при нормальном распределении) или как медиана (Me) и интерквартильный размах (IQR) (при асимметричном распределении). Для оценки прогностической значимости разных методов на риск наступления переменных интереса использовали одно- и многофакторные модели регрессионного анализа Кокса. На фоне стандартной терапии частота остаточного застоя по данным отдельных методик: УЗИ легких, НЭМ печени, БИВА и NT-proBNP — колеблется от 22 до 38%, субклинического — от 14,5 до 27%, количество пациентов, достигших компенсации, колебалось от 13,5 до 26%. При использовании интегральной оценки застоя частота остаточного застоя составила 53%, субклинического — 35%, группа компенсации — 5,4%
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