Abstract
BackgroundIntakes of selected vitamins and dietary fiber may influence the clinical course of systemic lupus erythematosus (SLE). Using a cohort study method, we investigated the associations of dietary intake of vitamin B6 and B12, folate, and dietary fiber with the risk of active disease and atherosclerotic vascular events in SLE.MethodsThe study included female SLE patients in the Miyagi Lupus Cohort, which was founded in 1995. Dietary nutrients at baseline were estimated by a semiquantitative food frequency questionnaire. The association of each nutrient intake with the risk of active disease was investigated in 216 patients who had inactive disease at baseline. The association with atherosclerotic vascular events was assessed in 196 women who had inactive disease and no history of atherosclerotic diseases at baseline.ResultsForty-three cases of active disease were identified during 9966 person-months of follow-up (1995–1999). During 19 575 person-months of follow-up (1995–2005), 20 atherosclerotic vascular events were documented. The Cox proportional hazards model revealed an inverse association between vitamin B6 intake and the risk of active disease (hazard ratio for the highest as compared with the lowest tertile, 0.41; 95% confidence interval, 0.18–0.97; P for trend = 0.04). An inverse association was also found for dietary fiber intake (P for trend = 0.01). However, no significant association was observed between intakes of these nutrients and the risk of atherosclerotic vascular events.ConclusionsHigher intake of vitamin B6 and dietary fiber may prevent the occurrence of active disease in SLE.
Highlights
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by abnormal immune responses resulting in the production of autoantibodies, generation of immune complexes, and activation of the complement system
In the crosssectional analysis of baseline data, we found some differences in nutrient intake between patients who had active and inactive disease: patients with active disease consumed a smaller amount of total fat and a larger amount of carbohydrate than those in the inactive phase
In the present prospective study of patients with systemic lupus erythematosus (SLE), we found that intakes of vitamin B6 and dietary fiber were inversely associated with the risk of active disease
Summary
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by abnormal immune responses resulting in the production of autoantibodies, generation of immune complexes, and activation of the complement system. Intakes of selected vitamins and dietary fiber may influence the clinical course of systemic lupus erythematosus (SLE). Using a cohort study method, we investigated the associations of dietary intake of vitamin B6 and B12, folate, and dietary fiber with the risk of active disease and atherosclerotic vascular events in SLE. The association of each nutrient intake with the risk of active disease was investigated in 216 patients who had inactive disease at baseline. The association with atherosclerotic vascular events was assessed in 196 women who had inactive disease and no history of atherosclerotic diseases at baseline. No significant association was observed between intakes of these nutrients and the risk of atherosclerotic vascular events. Conclusions: Higher intake of vitamin B6 and dietary fiber may prevent the occurrence of active disease in SLE
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
