Abstract
ObjectiveTo estimate the prevalence of DR and to correlate cardiometabolic, sociodemographic, and oxidant/antioxidant imbalance data to the prevalence of DR.DesignThis case-control study included type 2 DM (T2 DM) patients with DR (n = 66), T2 DM patients without DR (N = 84), and healthy controls (n = 45) without DR, in Kinshasa town. Diet, albuminemia, serum vitamins, and 8-isoprostane were examined.ResultsNo intake of safou (OR = 2.7 95% CI 1.2–5.8; P = 0.014), low serum albumin <4.5 g/dL (OR-2.9 95% CI 1.4–5.9; P = 0.003), no intake of fumbwa (OR = 2.8 95% CI 1.2–6.5; P = 0.014), high 8-isoprostane (OR = 14.3 95% CI 4.5–46; P<0.0001), DM duration ≥5 years (OR = 3.8 95% CI 1.6–9.1; P = 0.003), and low serum vitamin C (OR = 4.5 95% CI 1.3–15.5; P = 0.016) were identified as the significant independent determinants of DR.ConclusionThe important role of oxidant/antioxidant status imbalance and diet is demonstrated in DR.
Highlights
Diabetic retinopathy (DR) is a progressive and long-term microvascular complication of diabetes mellitus (DM) defined by defects in insulin metabolism and dysfunction in carbohydrate, lipid and protein metabolism
The important role of oxidant/antioxidant status imbalance and diet is demonstrated in DR
The preventive role of intake of vegetables rich in antioxidants, control of chronic hyperglycemia, early detection of microalbuminuria, control of dyslipidemia, control of arterial hypertension and vitamins supplements against metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and diabetic complications is reported within sub-Saharan Africa and outside Africa [5,6,7,8]
Summary
Diabetic retinopathy (DR) is a progressive and long-term microvascular complication of diabetes mellitus (DM) defined by defects in insulin metabolism and dysfunction in carbohydrate, lipid and protein metabolism. With a prevalence rate of 31.6% in the tertiary hospital of the city of Kinshasa [3], capital of DRC (Central region of Africa), DR is the commonest microvascular complication of DM and seems to be one of leading causes of visual disability including visual impairment and blindness [4]. In this environment, pregnancy, family history of DM, longer DM duration and higher pulse pressure (arterial stiffness) are the important and independent risk factors of DR [3]. African pear safou (Dacryodes edulis) [9] and fumbwa vegetables (GNETUM AFRICANUM), popular food plants in tropical Africa, are well known for their high concentrations in antioxidants [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
