Abstract
BackgroundSeveral prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes.MethodsPubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model.ResultsA total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04–1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91–1.18, p = 0.62).ConclusionsOur findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.
Highlights
Type 2 diabetes, one of the main causes of morbidity and mortality, has significantly increased worldwide in recent years
Sugar-sweetened beverage (SSB) consumption decreased among youth and adults in the United States between 1999 and 2010 [1], an increased intake of these beverages was observed in Asians [2]
Several prospective studies suggested that higher intake of sugar-sweetened fruit juice may increase the risk of developing type 2 diabetes [5,10], while others showed no significant association for 100% fruit juice [6,8,9]
Summary
Type 2 diabetes, one of the main causes of morbidity and mortality, has significantly increased worldwide in recent years. To date, the findings of the association between fruit juice intake and risk of type 2 diabetes are mixed according to type of fruit juice [5,6,7,8,9,10,11]. Several prospective studies suggested that higher intake of sugar-sweetened fruit juice may increase the risk of developing type 2 diabetes [5,10], while others showed no significant association for 100% fruit juice [6,8,9]. Several prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. We aimed to estimate the association between fruit juice intake and risk of type 2 diabetes
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