Intake of different types of red meat, poultry, and fish and incident colorectal cancer in women and men: results from the Malmö Diet and Cancer Study

Alexandra Vulcan,Jonas Manjer,Ulrika Ericson,Bodil Ohlsson

doi:10.1080/16546628.2017.1341810

Alexandra Vulcan, Jonas Manjer + Show 2 more

Open Access

https://doi.org/10.1080/16546628.2017.1341810

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Abstract

ABSTRACTBackground: Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development.Objective: This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations.Design: In the Malmö Diet and Cancer Study, dietary data was collected through a modified diet history method. Via the Swedish Cancer Registry, 728 cases of CRC were identified during 428 924 person-years of follow-up of 16 944 women and 10 987 men.Results: Beef intake was inversely associated with colon cancer. However, in men high intake of beef was associated with increased risk of rectal cancer. High intake of pork was associated with increased incidence of CRC, and colon cancer. Processed meat was associated with increased risk of CRC in men. Fish intake was inversely associated with risk of rectal cancer. No significant interactions were found between different types of meat and weight status.Conclusions: Findings suggest that associations between meat intake and CRC differ depending on meat type, sex, and tumor location in the bowel. Weight status did not modify observed associations.

Highlights

Colorectal cancer (CRC) is estimated to be one of the most common forms of cancer in the Western world [1,2]
Fish intake was inversely associated with rectal cancer
Previous meta-analyses have indicated significant associations between high intake of processed meat and colon cancer, but not with rectal cancer [6,8], Bernstein et al [8] concluded that they could not find evidence to show that the associations differed with colon or rectal cancers, but that the intake of processed red meat was especially associated with increased risk of distal colon cancer

Summary

Introduction

Colorectal cancer (CRC) is estimated to be one of the most common forms of cancer in the Western world [1,2]. Geographic area, as seen in a metaanalysis by Ma et al [4] Other lifestyle factors, such as diet, are considered to be associated with risk of CRC. The World Cancer Research Fund and the American Institute for Cancer Research (WCRF/ AICR) have concluded that there is convincing evidence that high intakes of red and processed meat are associated with increased risk of CRC [5]. Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. Objective: This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. In men high intake of beef was associated with increased risk of rectal cancer.

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