Abstract
Oxidized low-density lipoprotein (Ox-LDL) is known to be highly atherogenic. Thus, decreasing the blood levels of Ox-LDL through dietary means is an important approach to reduce cardiovascular events in high-risk individuals. In this randomized placebo-controlled human interventional trial, we aimed to evaluate whether Perilla frutescens leaf powder (PLP) ameliorates Ox-LDL and home blood pressure, along with its biological antioxidant potential. Healthy Japanese volunteers aged 30–60 years (n = 60) were randomized to PLP and placebo groups. The PLP group consumed PLP dried using a microwave under reduced pressure, and the placebo group consumed pectin fiber daily for 6 months. Home blood pressure, serum biochemical parameters, and fatty acid profiles of erythrocyte plasma membranes were analyzed. Plasma Ox-LDL levels significantly decreased in the PLP group but not in the placebo group. Mean changes in the biological antioxidant potential and alpha-linolenic acid levels in the erythrocyte plasma membrane were significantly increased in the PLP group than in the placebo group. In subjects with prehypertension (systolic blood pressure [SBP] ≥ 120 mmHg), the mean reduction in morning or nocturnal SBP was significantly greater in the PLP group than in the placebo group. Thus, PLP intake may be an effective intervention to prevent cardiovascular diseases.
Highlights
The seed of Perilla frutescens is used to derive vegetable oil, namely perilla oil
We previously reported that perilla leaf powder (PLP), microwave dried under reduced pressure, reduced the risk of metabolic syndrome in the SHR.Cg-Leprcp /NDmcr (SHR-cp) rat model [17]
This study included a total of 30 subjects, who were randomly allocated to the Perilla frutescens leaf powder (PLP) group and placebo group
Summary
The seed of Perilla frutescens is used to derive vegetable oil, namely perilla oil. In addition to its seed oil, the leaves of P. frutescens have numerous applications, such as a popular garnish in foods inJapan, China, and Korea [1,2]; as a preservative; and for medicinal purposes, such as in the treatment of colds, food poisoning [3], food allergy [4], and depression [5]. In addition to its seed oil, the leaves of P. frutescens have numerous applications, such as a popular garnish in foods in. Red-colored perilla leaves are frequently used as a food colorant owing to the presence of anthocyanins and other related compounds, which themselves have free radical-scavenging potential [6] and anti-lipid peroxidation effects [7]. Phenolic compounds, such as rosmarinic acid, luteolin, apigenin, and α-linolenic acid.
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