Insurance Request and Approval Process for Proton Beam Therapy in Patients with Esophageal Cancer

Abstract

Randomized data suggests proton beam therapy (PBT) reduces the risk and severity of toxicities when compared to IMRT in the neoadjuvant or definitive setting for esophageal cancer. As a critical barrier to access to PBT, we investigate our institutional experience with the prior authorization (PA) process for patients (pts) with esophageal cancer. One hundred and four (104) consecutive pts with esophageal cancer from 2016-2020 at one institution for whom PBT was recommended were analyzed. Data was collected from the customer relations management (CRM) database and electronic health record. Patient characteristics, tumor characteristics, treatment parameters, types of insurance, and clinical outcomes (OS, LF, DF) were recorded. Timepoints of the steps of the PA process included the PA team's initial inquiry, the initial decision, first through third appeals, and outcomes of each appeal (the third of which was regarded as the final decision). Rates of approval and successful appeal were calculated. Logistic and Cox regression models were used to evaluate whether insurance decisions were associated with clinical factors or clinical outcomes. Approval rates by Medicare (n = 68) and private insurance (n = 36) were 100 and 42% on initial request, at a median (range) 0 and 3 (0-15) days from inquiry to determination, respectively. All 21 pts initially denied coverage appealed the decision. Overall, denial was overturned in 48% of pts (median [range] time, 14 [7-36] days from initial inquiry [FIQ]), i.e., PBT was eventually approved for them. The remaining pts proceeded with self-pay or photon therapy. Upon first appeal, 14 pts were denied (median [range] time, 7 [1-26] days FIQ). Upon second appeal, 6 pts were denied (median [range] time, 18 [7-34] days FIQ). Finally, upon third appeal, 2 pts were denied and 1 patient was approved (median [range] time, 2 [20-39] days). Medicare insurance (P < .01) and possessing secondary insurance (P = .02) were found to be associated with increased likelihood of initial approval. Notably, a trend was found between clinical trial enrollment and decreased likelihood of initial approval. Neither initial nor final insurance decisions were found to be associated with OS, LF, or DF. Despite randomized data and policy efforts supporting the use of PBT in esophageal cancer, pts with private payers experience treatment delays and often eventual denial after appeal.