Abstract
In their respective textbooks Joslin, 1 Wilder 2 and Duncan 3 have stated that injections of protamine zinc insulin are more apt to produce cutaneous reactions than regular insulin. During an experience of seven years we have found that globin insulin (with zinc) has only rarely been followed by cutaneous reactions. Bauman 4 found that several patients who had severe skin reactions after injections of protamine zinc insulin obtained immediate relief when globin insulin (with zinc) was substituted. Duncan 5 replaced protamine zinc insulin with globin insulin (with zinc) in 2 patients and noted a disappearance of the irritation of the skin. In the article published by Bailey and Marble 6 local reactions were not encountered when globin insulin (with zinc) was used. As the question of sensitivity to insulin is of some practical importance and because we wanted to see if the results of cutaneous tests with uncombined protamine
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