Abstract
1. 1. The apical membrane of fetal distal lung epithelium had two types of amiloride-blockable Na +-permeant cation channels; (1) nonselective cation (NSC) channel with a single channel conductance of 27 pS and (2) Na + channel with a single channel conductance of 12 pS around resting membrane potential. 2. 2. The IC 50 of amiloride to the Na + channel was 1–2 μM, while the IC 50 of amiloride to the NSC channel was less 1μM. The open probability of the Na + channel was about 10-fold larger than that of the NSC channel. 3. 3. Insulin (100 nM) increased the open probability of both channels.
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