Insulina aspart en pacientes con diabetes tipo 2

Abstract

Current insulin therapy aims to mimic both basal and prandial physiological hormone secretion to achieve near-normal glycemia. Regular human insulin has been used for years for glycemic control in type 2 diabetes mellitus (DM-2). However, its pharmacokinetic and pharmacodynamic profiles have never been considered optimal. Due to its more physiological profile, insulin aspart has gradually been substituting regular human insulin in patients with DM-2 but there is ongoing debate concerning its efficacy and safety in these patients. Although insulin aspart has not been shown to produce significant decreases in HbA1c, some – but not all – studies have reported that this drug has beneficial effects in reducing postprandial hyperglycemia. Furthermore, at least in specific populations, insulin aspart may reduce the incidence of nocturnal hypoglycemic episodes and severe hypoglycemic episodes, a finding of importance in high-risk patients.