Insulin values of normal pancreatic and pancreatic adenomas tissue extracts in children

Abstract

Tissues of four pancreatic adenomas of children with clinical hyper-insulinemia and relative hyperinsulinemia, and normal pancreatic tissue were studied. Tissues were extracted and immunoreactive insulin levels measured per gram of dry tissue. Comparisons of findings in two newborn babies with inverted rate glucose/insulin and two children of 11 and 14 yr of age with hyper-insulinemia are reported. Results indicate relative comparable insulin values in adenoma pancreatic tissue in both age groups per gram of tissue, although larger amounts of circulating immunoreactive insulin were found in older children with true hyperinsulinemia. High insulin concentrations were found in one case. These high levels may be related to the severity or type of cell adenoma.