Abstract

One of the hallmarks of diabetes, a metabolic disease caused by a lack of secretion, work, or both insulins, is hyperglycemia. Although insulin is the most effective treatment for diabetes mellitus, most patients are reluctant to inject insulin. A problem that can arise from not taking insulin as prescribed at the initial dose is cardiovascular disease, which is a leading cause of morbidity and death in diabetics. The goal is to analyze the administration of insulin therapy in diabetic individuals who receive it. The PICO Strategy method is applied to research topics using populations/problems, interventions, comparisons, outcomes, and keywords relevant to Sciencedirect, PubMed, Nelitik, and Google Scholar (in Indonesian and English). The results of the review obtained were the compliance of Diabetes Mellitus (DM) patients in undergoing therapy, some participants were obedient to undergo insulin therapy regularly. Conclusion factors of non-compliance with insulin therapy often arise fear of hypoglycemia, discomfort and fear in using insulin injections

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