Abstract
On using Sakel's (1) method of insulin therapy on patients with schizophrenia and other functional types of mental diseases, we were confronted by exigent problems. Some of these were the control of the reactions to prevent immediate disaster, the observing of the early changes that might occur, especially in the metabolic processes, and the persistent search for similar late changes. We were particularly interested in seeing whether or not this rather drastic disruption of the endocrine mechanism might produce undesirable changes in the endocrine system. The mental diseases requiring treatment were serious enough to warrant our taking reasonable chances. In December 1936 we began using insulin shock therapy in schizophrenia. Since then we have so treated 37 patients with schizophrenia, 9 with manic depressive psychosis, 6 with melancholia and 2 patients with psychasthenia. Nine of these patients had an associated thyrotoxicosis.
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