Abstract

and placental compartments, where in some cases dysregulated functions have been associated with adverse pregnancy outcomes. Recent studies highlight the contribution of galectins, a family of endogenous glycan-binding proteins, to critical biological events occurring during mammalian gestation, including immune cell tolerance, inflammation, implantation, and angiogenesis. This lecture will summarize current knowledge on galectins as regulators of angiogenesis in early pregnancy and discuss their implication in preeclampsia, a life-threatening pregnancyspecific disorder.

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