Abstract
ORIGINAL RESEARCH article Front. Endocrinol., 14 October 2011Sec. Cellular Endocrinology https://doi.org/10.3389/fendo.2011.00054
Highlights
Other evidence supports the idea that hyperactivation of the PI3K/Tor pathway causes autism and autism spectrum disorders (ASDs)
Other evidence supports the idea that hyperactivation of the PI3K/Tor pathway causes autism and ASD
These observations and others have led to the proposal that at least some of the deficits in autism might reflect increased sensitivity to metabotropic glutamate receptors (mGluR)-long term depression (LTD) induction (Bear et al, 2004; Kelleher and Bear, 2008) as a consequence of hyperactivation of the PI3K/Tor pathway
Summary
Other evidence supports the idea that hyperactivation of the PI3K/Tor pathway causes autism and ASD. The PI3K/Tor signaling pathway affects a form of synaptic plasticity that has been implicated in autism (Bear et al, 2004).
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